Pro DNA – Paris Hilton Skincare

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ProD.N.A.® and Science of Aging

Meet Dr. Ershadi

Valeria Sadigh Ershadi, MD, ProD.N.A. Brand Dermatologist, has dedicated her seasoned career to understanding the complex relationship between skin and the inner workings of the human body.

Dr. Ershadi practices Clinical Dermatology in Milan, Italy, and focuses specifically on advancing skin cancer research. As a philosophy, she emphasizes the importance of unearthing one’s natural beauty without the use of surgery or injections, rather, improving the skin through healthy lifestyle choices and quality skincare products.

Educated at the University of Pavia, the most prestigious medical school in Italy, Dr. Ershadi practiced dermatology while she simultaneously rose to become one of the most appreciated specialists in the fields of cutaneous oncology and autoimmune diseases. Additionally, Dr. Ershadi has contributed to the drafting of several books on clinical cosmetics and dermatology, while also collaborating with prevalent publications on the topic of skincare.

A Closer Look Into The Science Of Aging

A combination of two culprits causes skin to age: the natural aging process and exposure to sunlight


Natural aging, also called “Intrinsic Aging” or chronological aging,” effects our DNA and is guided by the nature of our genes. Its speed varies from person to person, and there’s nothing one can do reverse this process at its source.

Intrinsic aging begins in our mid-20s and continues throughout our lives, even though it’s effects may not become evident for decades.

As time progresses, the body’s chemistry shifts and the structural basis of your skin (collagen and elastin) begin to break down. This phenomenon prevents the skin from regaining its shape at its previous speed, and wrinkles, visible expression lines, and saggy skin will slowly emerge on one’s complexion.


The second type of aging we experience is called extrinsic aging, which is caused by factors outside of the body.

The responsible parties include UV rays (UVA and UVB), pollution, cigarette smoke and other environmental factors, and high-energy visible (HEV) light, or, “blue light.”

HEV light is primarily from the sun, but is also emitted by your smartphone, tablet and computer screen. Extrinsic Aging leads the skin to develop new dark spots, wrinkles and a dull, greyish color.


UV rays cause inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis.

Solar UV exposure is a major factor for age-related changes such as skin cancer development, hyperpigmentation, fine lines, and wrinkles.

UV radiation produces both direct and indirect DNA damage, and each can result in mutagenesis in skin cells. UV exposure may account for up to 80% of the visible signs of aging in the skin including dryness, wrinkles, loss of skin tone, hyperpigmentation and photoaging. These factors all correlate with an increased risk of skin cancer.

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